RP14

When to start ART? A replication study of timing of antiretroviral therapy for HIV-1-associated Tuberculosis

3ie Replication paper 14

Eric W. Djimeu

In this paper, the research team conducted a replication study of Havlir and others’ 2011 study, “Timing of antiretroviral therapy for HIV-1 infection and tuberculosis.” The original study tackled the issue of optimal timing for ART initiation in HIV-TB co-infected patients by conducting a large multisite trial in 26 countries to determine the impact of earlier ART (within 2 weeks of the initiation of treatment for tuberculosis) on new AIDS-defining illness and death. The original authors find that earlier ART initiation reduces the rate of new AIDS-defining illness and death only for HIV positive TB patients with a CD4 count lower than 50.

In this replication study, the researcher team conducted a pure replication and measurement and estimation analyses. In general, the pure replication confirmed the main findings of the original paper. In addition, the research team found that earlier ART initiation is associated with a sharp increase in the incidence of TB-associated immune reconstitution inflammatory syndrome (IRIS). Furthermore, using mainly econometric approaches to increase the statistical power of the study and to estimate the treatment effect on patients who actually received earlier ART. The research team find that earlier ART initiation do not reduce the rate of new AIDS-defining illness and death even for HIV-positive TB patients with CD4 counts lower than 50.

Overall, the results of this replication do not provide strong support that earlier ART initiation reduces the rate of new AIDS-defining illness and death only for HIV-positive TB patients with CD4 counts lower than 50.

Biometric Smartcards and payment disbursement: a replication study of a state capacity-building experiment in India

Biometric Smartcards and payment disbursement: a replication study of a state capacity-building experiment in India

Replication paper 3ie 2019
The National Rural Employment Guarantee Scheme and Social Security Pension are two of the largest employment programmes in Andhra Pradesh. Muralidharan and colleagues (2016) investigated the impacts of biometrically-authenticated payment infrastructure (Smartcards) on beneficiaries of the two employment programmes.

RPS22

Risk sharing and transaction costs: a replication study of evidence from Kenya’s mobile money revolution

Replication paper 3ie 2019
This replication study starts with the twin strategies of push-button and pure replications of the original study. It then followed this up with various consistency and robustness checks, such as propensity score matching and the Tobit model specification.

Cash and change: a replication study of a cash transfer experiment in Malawi

Cash and change: a replication study of a cash transfer experiment in Malawi

Replication paper 3ie 2019
Maira Reimão conducted a replication of a 2011 study, Cash or condition? Evidence from a cash transfer experiment, by Baird and colleagues, which is one of the few studies that empirically compares the impact of unconditional cash transfers to that of conditional cash transfers.

Impact of unconditional cash transfers: a replication study of the short-term effects in Kenya

Impact of unconditional cash transfers: a replication study of the short-term effects in Kenya

Replication paper 3ie 2019

Wang and colleagues replicate the results of a randomized evaluation carried out by Haushofer and Shapiro in 2016.

3ie Replication paper 18

Savings revisited: a replication study of a savings intervention in Malawi

Replication paper 3ie 2018

Jesper Stage and Tharshini Thangavelu replicate the results of a randomized evaluation carried out by Lasse Brune and colleagues in 2016 in Malawi.