Pure replication completed

This page lists all 3ie replication programme studies with completed pure replications.

3ie defines pure replication as the attempt by replication researchers to reproduce the original results using the same data and published methodology from the original paper. After review and comments from the internal and external project advisors, these replications studies will be revised and completed.

Pure Replication Completed

Pure replication completed

Universal test and treat and the HIV epidemic in rural South Africa: a phase 4, open-label, community cluster randomized trial

Replication study
Replication researchers: Sridevi Prasad
Original paper title:

Universal test and treat and the HIV epidemic in rural South Africa: a phase 4, open-label, community cluster randomized trial


Original researchers: Collins C Iwuji MRCP, Joanna Orne-Gilemann PhD, Joseph Larmarange PhD, Eric Balestre MPH, Prof Rodolphe Thiebault PhD, Prof Frank Tanser PhD, Nonhlanhla PhD, Thembisa Makowa BA, Jaco Dryer NDip, Kobus Herbst Msc, Prof Nuala McGrath ScD, Prog Till Barningh
Original publication: The Lancet
Replication plan:

Prasad & Holmes’ replication plan


Current status: Pure Replication Completed

Prevention of HIV-1 Infection with Early Antiretroviral Therapy

Replication study
Replication researchers: Eric Djimeu, Eleanor Dickens
Original paper title:

Timing of Antiretroviral Therapy for HIV-1 Infection and Tuberculosis


Original researchers: Myron S. Cohen, Ying Q. Chen, Marybeth McCauley, Theresa Gamble, Mina C. Hosseinipour, Nagalingeswaran Kumarasamy, James G. Hakim, Johnstone Kumwenda, Beatriz Grinsztejn, Jose H.S. Pilotto, Sheela V. Godbole, Sanjay Mehendale, Suwat Chariyalertsak, Breno R. Santos, Kenneth H. Mayer, Irving F. Hoffman, Susan H. Eshleman, Estelle Piwowar-Manning, Lei Wang, Joseph Makhema, Lisa A. Mills, Guy de Bruyn, Ian Sanne, Joseph Eron, Joel Gallant, Diane Havlir, Susan Swindells, Heather Ribaudo, Vanessa Elharrar, David Burns, Taha E. Taha, Karin Nielsen-Saines, David Celentano, Max Essex, Thomas R. Fleming
Original publication: New England Journal of Medicine
Replication plan:

Eric W Djimeu and Anna Heard's replication plan


Current status: Pure Replication Completed