HIV Combination Prevention Programme

HIV Combination Prevention Programme

3ie, funded by the Bill & Melinda Gates Foundation, is supporting studies and other work on HIV combination prevention to maximize the useful knowledge and policy implications from these interventions.

Overview of activities

3ie will be supporting five activities through this programme.

Universal test and treat and the HIV epidemic in rural South Africa: a phase 4, open-label, community cluster randomised trial: 3ie funded and provided technical guidance to the ANRS 12249 Treatment as Prevention (TasP) trial. This trial assessed if a universal HIV testing and treatment program would be effective at reducing HIV incidence at the population level in South Africa.

Effect of Universal Testing and Treatment on HIV Incidence – HPTN 071 (PopART): 3ie funded and provided technical guidance to the HPTN 071 PopART trial. This study assessed if a combination prevention program, which included a universal HIV testing and treatment component, would reduce HIV incidence at the population level in South Africa and Zambia.

Partnership with UNAIDS: 3ie is funding UNAIDS to develop technical standards for monitoring HIV prevention programs that can be used by the global community. The final product will be translated into French, Spanish, and Russian.

Partnership with Africa Health Research Institute: 3ie is funding the Africa Health Research Institute to conduct a study in South Africa that is using a human-centered approach to integrate antiretroviral therapy-based HIV prevention with other health services to improve adolescents’ and young adults’ sexual and reproductive health. The overall goal of this study is to reduce HIV incidence and improve sexual and reproductive health outcomes.

Replication studies: As part of this program, 3ie initially funded five replication studies through the Replication programme on HIV prevention (Replication Window 3). At the request of the Gates Foundation, 3ie is funding three additional replications:

Related content

Cash transfers and HIV/HSV-2 prevalence: a replication of a cluster randomized trial in Malawi

Replication paper 3ie 2017
In this paper, Lynette Smith, Nick Hein and Danstan Bagenda conduct a replication study of the influential 2012 publication, Effect of a cash transfer programme for schooling on prevalence of HIV and herpes simplex type 2 in Malawi.

PEPFAR and adult mortality: a replication study of HIV development assistance effects in Sub-Saharan African countries

Replication paper 3ie 2018
Nicholas Hein and colleagues conducted a replication of the 2012 publication HIV development assistance and adult mortality in Africa by Eran Bendavid and colleagues.

Stretching HIV treatment: A replication study of task shifting in South Africa

Replication paper 3ie 2017
Baojiang Chen and Morshed Alam conducted a replication study of Fairall and other’s influential paper, “Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH)”.

Preventing HIV and HSV-2 through improving knowledge and attitudes: a replication study of a multicomponent intervention in Zimbabwe

Replication paper 3ie 2018
Yu and colleagues conducted a replication study of an influential paper “The Regai Dzive Shiri Project: results of a randomised trial of an HIV prevention intervention for Zimbabwean youth” by Frances Cowan and colleagues.

Treatment as prevention: a replication study on early antiretroviral therapy initiation and HIV-1 transmission

Replication paper 3ie 2020
Eric Djimeu and Eleanor G Dickens conduct a replication of the HPTN 052 study by Cohen and colleagues that evaluates the impact of early initiation of antiretroviral therapy on rates of sexual transmission of HIV-1.

There are no impact evaluations
There are no systematic reviews
There are no evidence gap maps

Treatment as prevention: a replication study on early antiretroviral therapy initiation and HIV-1 transmission

Replication paper 3ie 2020
Eric Djimeu and Eleanor G Dickens conduct a replication of the HPTN 052 study by Cohen and colleagues that evaluates the impact of early initiation of antiretroviral therapy on rates of sexual transmission of HIV-1.

Preventing HIV and HSV-2 through improving knowledge and attitudes: a replication study of a multicomponent intervention in Zimbabwe

Replication paper 3ie 2018
Yu and colleagues conducted a replication study of an influential paper “The Regai Dzive Shiri Project: results of a randomised trial of an HIV prevention intervention for Zimbabwean youth” by Frances Cowan and colleagues.

PEPFAR and adult mortality: a replication study of HIV development assistance effects in Sub-Saharan African countries

Replication paper 3ie 2018
Nicholas Hein and colleagues conducted a replication of the 2012 publication HIV development assistance and adult mortality in Africa by Eran Bendavid and colleagues.

Stretching HIV treatment: A replication study of task shifting in South Africa

Replication paper 3ie 2017
Baojiang Chen and Morshed Alam conducted a replication study of Fairall and other’s influential paper, “Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH)”.

Cash transfers and HIV/HSV-2 prevalence: a replication of a cluster randomized trial in Malawi

Replication paper 3ie 2017
In this paper, Lynette Smith, Nick Hein and Danstan Bagenda conduct a replication study of the influential 2012 publication, Effect of a cash transfer programme for schooling on prevalence of HIV and herpes simplex type 2 in Malawi.

There is no related content.